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KMID : 0369820040340040289
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Jorunal of Korean Pharmaceutical Sciences
2004 Volume.34 No. 4 p.289 ~ p.297
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Effect of Types and Mixing Ratios of Water-Soluble Polymers on In Vitro Release Profile of Solid Dispersion for Acyclovir
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안용산/Ahn YS
이하영/홍금덕/정성범/조선행/이종문/이해방/강길선/Lee HY/Hong KD/Jung SB/Cho SH/Rhee JM/Lee HB/Khang GS
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Abstract
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Acyclovir (ACV) is one of the most effective and selective agents against viruses of the herpes group. Because of low solubility, bioavailability of ACV has shown below 30% with oral dosage form. In our previous study, we reported that the fabrication of solid dispersion of ACV was possible and the solid dispersion of ACV and PVP was the most useful in all samples. In this study, we examined the effect of mixture ratio of polymers (PEG and PVP) to ACV. Solubility of ACV was dramatically increased up to 25 mg/ml in 80?C distilled water. So water was used as a solvent to eliminate problem of residual solvent. Spray drying method was used for the solid dispersion of ACV as solvent extraction. Different scanning calorimeter was used to check degradation of drug. Polymer carriers were PEG 6,000 and PVP. In summary, ACV-PVP (1:3) showed the best solubility in distilled water.
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KEYWORD
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Acyclovir, Solid dispersion, Water, PEG, PVP
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